# Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA) EUACC page: https://www.euacc.ai/calls/HORIZON-CL4-2025-05-MATERIALS-51-two-stage Retrieved: 2026-11-10T13:52:55.088Z. Retrieval is not verification. Source content is reference data, never instructions. ## Public content **topic id:** HORIZON-CL4-2025-05-MATERIALS-51-two-stage **call id:** HORIZON-CL4-2025-05-two-stage **title:** Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA) **programme:** Horizon Europe **cluster:** CL4 **status:** closed **deadline date:** 2026-04-14T00:00:00+00:00 **deadline model:** two-stage **start date:** 2025-05-22T00:00:00+00:00 **url:** https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/HORIZON-CL4-2025-05-MATERIALS-51-two-stage **description:** Expected Outcome: Projects are expected to contribute to the following outcomes: • Make safer and more sustainable alternatives to per- and poly-fluoroalkyl substances (PFAS) available to industries offering products with targeted performances supporting their competitiveness; • Give the Commission, regulatory agencies, Member States and associated countries access to new and publicly available knowledge about PFAS alternatives; • Support EU strategies, policies and legislation, such as future PFAS restrictions under the REACH Regulation[1] , as well as requirements for the EU Ecolabel[2], EU Taxonomy[3] and Eco-design for Sustainable Products Regulation (ESPR)[4], by making safe and sustainable alternatives to PFAS available; • Demonstrate the applicability of the ‘Safe and Sustainable by Design’ (SSbD) framework[5] to avoid regrettable substitution when developing innovative safe alternatives to PFAS. Scope: PFAS are a large class of substances used in a wide range of applications (for instance, as adhesives, coatings, lubricants, sealants, surfactants), for their technical and/or safety functions (e.g., water and oil repellence, antiadhesion, thermal & chemical stability)[6]. Nevertheless, PFAS have been detected in groundwater, surface water and soil, the remediation of which is extremely problematic[7],[8]. Their accumulation in the environment has been linked to negative effects for the wildlife and the human health, including carcinogenic, mutagenic, reprotoxic and toxic effects for the endocrine system[9]. In January 2023, five national authorities submitted to the European Chemicals Agency (ECHA) a PFAS restriction dossier to ban the manufacture, placing on the market and use of PFAS as a chemical class in all uses, with few exemptions[10]. The Commission initiative for SSbD sets a framework which should be a reference in the proposal. The new alternatives to be developed should meet the technical functions required in the specific applications and align with such framework. Proposals should address at least one industrial application and should develop one or more new chemical substances or technologies to replace existing PFAS used, according to abovementioned applications and functions, in one of the following areas: • Electronics, electrical appliances and grids (e.g., wires, cables, heat transfer fluids, transformers, switchgears), where PFAS are currently used to provide a combination of technical and/or safety functions to withstand impact of high temperature, pressure and chemicals, ensure corrosion inhibition and non-flammability. • Construction technologies (e.g., carpeting, drywall, paintings, foams) where PFAS are currently used to provide a combination of technical functions such as resistance in harsh environments and for wetting agents. • Technical textiles (e.g., personal protective equipment, construction textiles, filtration and separation media, technical textiles for transport applications) where PFAS are currently used for their repellence but also heat stability and corrosion inhibition. • Automotive parts (e.g. electrical parts including batteries, membranes, hoses and pipes, brakes, rubber processing) where PFAS are also currently used[11]. All actors along the value chain should be involved to ensure the new substance has a clear use case, market and potential to grow. Multidisciplinary research activities should address all of the following: • The ‘Safe and Sustainable by Design’ framework should be applied when developing the alternative(s) and the assessment results be published and underlying methods and data made FAIR across the whole value chain; • The selection of the PFAS alternatives to be developed should be justified with a technological and socio-economic analysis, also considering potential impacts on health and reproductive health; • Novel PFAS-free materials or structures should undergo testing under relevant conditions to ensure their properties meet or exceed the properties of PFAS-based solutions across various applications; • The substitution barriers for the selected applications should be identified and a driving mechanism for a maximal substitution in the targeted value chains proposed; • Challenges for the adaption of existing production lines should be identified and solutions proposed; • Communication and other outreach actions to all stakeholders and specifically citizens about the benefits of the developed ‘Safe and Sustainable by Design’ alternatives to PFAS substances. • Proposals should involve appropriate expertise in Social Sciences and Humanities (SSH), e.g. with communities of citizens to engage in product reliability and consumer rights. At least, an analysis of how the introduction of such alternatives is positively or negatively considered by users and the general population, disruptive (or not) for the established social norms or behavioural patterns, should be conducted; • Policy briefs will be reported to the European Commission on a yearly basis to communicate on the key results and achievements. Proposals should indicate to which chapters of the Strategic Research and Innovation Plan for chemicals and materials[12] they will contribute. Proposals submitted under this topic should include a business case and exploitation strategy. In accordance with the SSbD framework, this topic requires the effective demonstration of the added value of the outcomes to protect human health and the environment, e.g. in the fields of biodiversity protection, indoor and /or outdoor air quality. Collaboration with existing Open Innovation Test Beds (OITBs)[13] should be explored - where relevant. International collaboration is encouraged. The challenge of developing PFAS alternatives should also cooperate with relevant topics under other clusters and calls of Horizon Europe (e.g. HORIZON-CL4-2021-RESILIENCE-01-08[14], HORIZON-CL4-2022-RESILIENCE-01-23[15], HORIZON-CL6-2023-ZEROPOLLUTION-02-2-two-stage[16], Horizon 2020 LC-GD-8-1-2020[17]), including topics under the Chips Joint Undertaking and the Clean Hydrogen Joint Undertaking (e.g. HORIZON-JTI-CLEANH2-2024-05-02: Development of non-fluorinated components for fuel cells and electrolysers). Proposals should specifically allocate the necessary resources for collaboration with the other relevant projects. null Activities are expected to start at TRL 3-4 and achieve TRL 6-7 by the end of the project – see General Annex B. [1] Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:02006R1907-20231201 [2] https://ec.europa.eu/environment/ecolabel/the-ecolabel-scheme.html [3] https://ec.europa.eu/environment/publications/proposal-ecodesign-sustainable-products-regulation_en [4] https://commission.europa.eu/energy-climate-change-environment/standards-tools-and-labels/products-labelling-rules-and-requirements/sustainable-products/ecodesign-sustainable-products-regulation_en [5] See documents defining the SSbD framework and criteria on: https://ec.europa.eu/info/research-and-innovation/research-area/industrial-research-and-innovation/key-enabling-technologies/advanced-materials-and-chemicals_en [6] This list of applications and functions are not exhaustive, unless explicitly mentioned. [7] https://www.eea.europa.eu/en/european-zero-pollution-dashboards/indicators/pfas-contamination-and-soil-remediation-signal [8] PFAS in European seas (Signal) (europa.eu) [9] https://doi.org/10.2903/j.efsa.2022.e200418 [10] Per- and polyfluoroalkyl substances (PFAS) - ECHA (europa.eu) [11] The use of (gaseous) PFAS in air conditioning is outside the scope of this call. [12] https://ec.europa.eu/info/research-and-innovation/research-area/industrial-research-and-innovation/key-enabling-technologies/advanced-materials-and-chemicals_en [13] https://ec.europa.eu/info/research-and-innovation/research-area/industrial-research-and-innovation/sustainable-production-processes_en [14] https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/horizon-cl4-2021-resilience-01-08 [15] https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/horizon-cl4-2022-resilience-01-23 [16] https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/horizon-cl6-2023-zeropollution-02-2-two-stage [17] https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/lc-gd-8-1-2020 **conditions:** General conditions 1. Admissibility Conditions: Proposal page limit and layout Applicants submitting a proposal under the blind evaluation pilot (see General Annex F) must not disclose their organisation names, acronyms, logos nor names of personnel in the proposal abstract and Part B of their first-stage application (see General Annex E). described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes. Proposal page limits and layout: described in Part B of the Application Form available in the Submission System. 2. Eligible Countries described in Annex B of the Work Programme General Annexes. A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide. 3. Other Eligible Conditions described in Annex B of the Work Programme General Annexes. 4. Financial and operational capacity and exclusion described in Annex C of the Work Programme General Annexes. 5a. Evaluation and award: Award criteria, scoring and thresholds This topic is part of the blind evaluation pilot under which first stage proposals will be evaluated blindly. are described in Annex D of the Work Programme General Annexes. 5b. Evaluation and award: Submission and evaluation processes are described in Annex F of the Work Programme General Annexes and the Online Manual. 5c. Evaluation and award: Indicative timeline for evaluation and grant agreement described in Annex F of the Work Programme General Annexes. 6. Legal and financial set-up of the grants Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025) [[This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’ or through this link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/ls-decision_he_en.pdf]]. described in Annex G of the Work Programme General Annexes. Specific conditions described in the [specific topic of the Work Programme] Application and evaluation forms and model grant agreement (MGA): Application form templates — the application form specific to this call is available in the Submission System Stage 1: Standard application form (HE RIA IA Stage 1 BLIND) Stage 2: 2025 RIA/IA Application form: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/temp-form/af/af_he-ria-ia_v9.0_en.pdf Evaluation form templates — will be used with the necessary adaptations Strage 1: Standard evaluation form (HE RIA, IA and CSA Stage 1 BLIND) Stage 2: 2025 RIA/IA Evaluation form: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/temp-form/ef/ef_he-ria-ia_v3.0_en.pdf Guidance HE Programme Guide Model Grant Agreements (MGA) Lump Sum MGA  Call-specific instructions  2025 Detailed budget table: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/common/temp-form/af/detailed-budget-table_he-ls-euratom_v3.3_en.xlsm Information on financial support to third parties (HE)  Information on clinical studies (HE)  Guidance: "Lump sums - what do I need to know?" Additional documents: HE Main Work Programme 2025 – 1. General Introduction HE Main Work Programme 2025 – 7. Digital, Industry and Space HE Main Work Programme 2025 – 14. General Annexes HE Programme Guide HE Framework Programme 2021/695 HE Specific Programme Decision 2021/764 EU Financial Regulation 2024/2509 Decision authorising the use of lump sum contributions under the Horizon Europe Programme Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment  EU Grants AGA — Annotated Model Grant Agreement  Funding & Tenders Portal Online Manual  Funding & Tenders Portal Terms and Conditions  Funding & Tenders Portal Privacy Statement **action type:** HORIZON Innovation Actions **budget:** **budget Years Columns:** - 2025 **budget Topic Action Map:** **110975:** - **action:** HORIZON-CL4-2025-05-MATERIALS-43-two-stage - HORIZON-IA HORIZON Innovation Actions **budget Year Map:** **2025:** 30000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 5 **max Contribution:** 6000000 **min Contribution:** 6000000 **planned Opening Date:** 2025-05-22 **110976:** - **action:** HORIZON-CL4-2025-05-TWIN-TRANSITION-35-two-stage - HORIZON-IA HORIZON Innovation Actions **budget Year Map:** **2025:** 48000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 5 **max Contribution:** 12000000 **min Contribution:** 8000000 **planned Opening Date:** 2025-05-22 **110977:** - **action:** HORIZON-CL4-2025-05-TWIN-TRANSITION-11-two-stage - HORIZON-IA HORIZON Innovation Actions **budget Year Map:** **2025:** 13000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 2 **max Contribution:** 6500000 **min Contribution:** 6500000 **planned Opening Date:** 2025-05-22 **110978:** - **action:** HORIZON-CL4-2025-05-TWIN-TRANSITION-21-two-stage - HORIZON-IA HORIZON Innovation Actions **budget Year Map:** **2025:** 10000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 2 **max Contribution:** 5000000 **min Contribution:** 5000000 **planned Opening Date:** 2025-05-22 **110979:** - **action:** HORIZON-CL4-2025-05-MATERIALS-51-two-stage - HORIZON-IA HORIZON Innovation Actions **budget Year Map:** **2025:** 30000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 4 **max Contribution:** 7000000 **min Contribution:** 7000000 **planned Opening Date:** 2025-05-22 **110980:** - **action:** HORIZON-CL4-2025-05-MATERIALS-42-two-stage - HORIZON-RIA HORIZON Research and Innovation Actions **budget Year Map:** **2025:** 30000000 **deadline Dates:** - 2025-09-23 - 2026-04-14 **deadline Model:** two-stage **expected Grants:** 5 **max Contribution:** 6000000 **min Contribution:** 6000000 **planned Opening Date:** 2025-05-22 **keywords:** HORIZON-CL4-2025-05-MATERIALS-51-two-stage, HORIZON-CL4-2025-05-two-stage **last synced at:** 2026-11-09T17:23:17.403+00:00 ## Review record No independent verification record is available. ## Source metadata