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This round is closed. Synced from the EU Funding & Tenders Portal on 9 November 2026.
Projects the EU funded under this call, with the organisation that led each one.
SCIANCEAI in Science
Led by Fondation Europeenne de la Science · France · 2025 · Official record ↗
Based on projects the EU funded on the same subject in this programme.
AI-DAPTAI-Ops Framework for Automated, Intelligent and Reliable Data/AI Pipelines Lifecycle with Humans-in-the-Loop and Coupling of Hybrid Science-Guided and AI Models
HORIZON-CL4-2023-HUMAN-01-01 · 2024 · Official record ↗
AI-CODEAI-CODE - AI services for COntinuous trust in emerging Digital Environments
HORIZON-CL4-2023-HUMAN-01-05 · 2023 · Official record ↗
AI REDGIO 5.0Regions and (E)DIHs alliance for AI-at-the-Edge adoption by European Industry 5.0 Manufacturing SMEs
HORIZON-CL4-2022-TWIN-TRANSITION-01-06 · 2023 · Official record ↗
EXPANSE AIEmpowering X-sector Pilots for EuropeAn and interNational Scale-up and compEtitiveness in AI
HORIZON-CL4-INDUSTRY-2025-01-HUMAN-63 · 2026 · Official record ↗
QPIC-AIAI-ENHANCED PHOTONIC QUANTUM NODES FOR SECURE COMMUNICATIONS
HORIZON-CL4-2025-03-DIGITAL-EMERGING-03 · 2026 · Official record ↗
AI-LinerAI:Liner - Data-driven sewer asset management: a path toward the resilient transformation of Europe's sewer infrastructure
HORIZON-CL4-2024-TWIN-TRANSITION-01-12 · 2025 · Official record ↗
AIS26AI IN SCIENCE SUMMIT 2026
HORIZON-CL4-2026-02-IBA · 2026 · Official record ↗
CEREBRA-AICEREBRA-AI: A unified framework for continual, explainable and embodied General-Purpose Artificial Intelligence
HORIZON-CL4-2025-04-DIGITAL-EMERGING-07 · 2026 · Official record ↗
Each one links to its EU funding record and the partners it works with: a starting list for building a consortium.
Expected Outcome:Projects are expected to contribute to the following outcomes:
Scope:Artificial intelligence is a game-changer for science and innovation, and promises significant opportunities to boost the European competitive edge in R&I that need to be capitalised on. The aim of the CSA is to structure AI-enabled research in Europe and assess options towards optimising the ecosystem for AI in Science in Europe, through a Strategic Research & Innovation Agenda and assessing the potential for possible future R&I initiative(s), in line with the recommendations of the Scientific Advice Mechanism[1], and the European Commission President’s political guidelines, for the setting up of an AI Research Council[2]..
The project should develop a Strategic Research and Innovation Agenda for AI in Science by mobilising large groups of domain and AI researchers in different fields to identify key long-term research challenges in a diverse range of scientific areas where AI can make a meaningful difference for scientific breakthroughs, which are compelling to the EU competitive, environmental and social policy agenda. The project should come up with pilot areas from across Horizon Europe Pillar II Clusters, building on Europe’s competitive advantages in science and AI technologies. The research challenges should be related to prediction and design problems in the different scientific fields identified that could be solved with AI.
The SRIA should also include areas where AI can improve generic scientific tasks e.g virtual research assistant / tools for literature-based discovery, for improving / enabling research workflows, lab automation and collaborative human-AI work in science. Research priority areas involving the use of models based on frugal AI, which are more compact, more efficient and less energy intensive, as well as human-centric and trustworthy AI for scientific work should also be explored.
The project should build evidence and assess the needs and potential for R&I initiatives for AI in Science beyond the CSA, in an effort to identify ways to improve the EU landscape for support for AI in Science, to be discussed and agreed upon with the Commission and the Member States. The assessment should identify the ways for improving data access, infrastructure and support services, as well as skills and talent-related needs to boost the integration of AI in different fields of science at larger scale in Europe in research processes and lab automation, while promoting reproducibility, transparency and open science. It should also identify options for EU to better enable cooperative development and sharing of AI models for scientific discovery across different scientific fields. It should also take into account existing EU efforts to support access to data, research infrastructures, networks, HPC.
Different scenarios of R&I initiatives and infrastructure improvements should be prototyped together with a diverse range of users and stakeholders from the research community, industry, start-ups, civil society and policy-maker communities. Based on the feasibility test results, the project should develop a roadmap on the needed steps for a more effective coordination between the domain and AI scientific communities in Europe and the needed upgrades in service and infrastructure provision at EU level for the integration of AI in different scientific fields, including research processes engaging citizens and civil society, e.g. Citizen Science.
The proposals should also provide coordination and dissemination for interdisciplinary AI-enabled science to facilitate stakeholder engagement, coordination and promotion of AI in Science initiatives across Europe. The CSA should develop a website, organise awareness raising events for the benefits of AI in Science and create opportunities for exchanging on good practices.
Projects should build on or seek collaboration with existing projects and develop synergies with other relevant European, national or regional initiatives, funding programmes and platforms, in particular with EU-level initiatives such as EOSC[3],EuroHPC Joint Untedtaking[4], ESFRI,[5]AI Factories,[6] the EU AI, Data and Robotics Partnership,[7]AI4EOSC[8] the AI on Demand Platform[9] and the GenAI4EU Central Hub.
[1] See European Commission’s Group of Chief Scientific Advisors (2024). Successful and timely uptake of artificial intelligence in science in the EU: scientific opinion. Brussels: European Commission.
[2] See Ursula von der Leyen, Political Guidelines For The Next European Commission 2024−2029
[3] Home | European Open Science Cloud - EU Node and the selected projects from the HORIZON-INFRA-2025-01-EOSC-04: Advancing AI-readiness and Machine-Actionability in the EOSC Ecosystem.
[4] Homepage - EuroHPC JU
[5] www.esfri.eu
[6] AI Factories | Shaping Europe’s digital future
[7] Adra Association
[8] AI4EOSC - AI4EOSC
[9] AI-On-Demand Portal - AIoD - AI on Demand
1. Admissibility Conditions: Proposal page limit and layout
described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes.
Proposal page limits and layout: described in Part B of the Application Form available in the Submission System.
2. Eligible Countries
described in Annex B of the Work Programme General Annexes.
A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
3. Other Eligible Conditions
described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion
described in Annex C of the Work Programme General Annexes.
5a. Evaluation and award: Award criteria, scoring and thresholds
are described in Annex D of the Work Programme General Annexes.
5b. Evaluation and award: Submission and evaluation processes
are described in Annex F of the Work Programme General Annexes and the Online Manual.
5c. Evaluation and award: Indicative timeline for evaluation and grant agreement
described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants
Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025). [[This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’ or through this link: https://ec.europa.eu/info/funding-tenders/opportunities/docs/2021-2027/horizon/guidance/ls-decision_he_en.pdf]].
described in Annex G of the Work Programme General Annexes.
described in the [specific topic of the Work Programme]
Application and evaluation forms and model grant agreement (MGA):
Application form templates — the application form specific to this call is available in the Submission System
Standard application form (HE CSA)
Evaluation form templates — will be used with the necessary adaptations 
Standard evaluation form (HE CSA) 
Guidance
HE Programme Guide 
Model Grant Agreements (MGA)
Lump Sum MGA 
Call-specific instructions 
Detailed budget table (HE LS) 
Information on financial support to third parties (HE) 
Information on clinical studies (HE) 
Guidance: "Lump sums - what do I need to know?"
Additional documents:
HE Main Work Programme 2025 – 1. General Introduction
HE Main Work Programme 2025 – 7. Digital, Industry and Space
HE Main Work Programme 2025 – 14. General Annexes
HE Programme Guide
HE Framework Programme 2021/695
HE Specific Programme Decision 2021/764
EU Financial Regulation 2024/2509
Decision authorising the use of lump sum contributions under the Horizon Europe Programme
Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment 
EU Grants AGA — Annotated Model Grant Agreement 
Funding & Tenders Portal Online Manual 
Funding & Tenders Portal Terms and Conditions 
Funding & Tenders Portal Privacy Statement
Applicants asked the EU 1 questions about this call and the EU published the answers. They clarify the call documents but do not replace them.
As explained in the AI Continent Action Plan, the previously announced European AI Research Council will be implemented as a Resource for AI Science in Europe (RAISE), pooling European resources to advance both the science of AI and the application of AI in science. Applications under this CSA topic should provide a unique opportunity to lay the groundwork for this strategic European initiative for AI in science, piloting some initial elements and functions for a central RAISE secretariat. Applications should support the coordination of networks of excellence and the broader AI in science stakeholder community, support access to pooled computing and data resources, and develop a cross-disciplinary strategic research and innovation agenda for AI in science.
Applicants are expected to closely interact and coordinate with the relevant European Commission’s services and EU-level initiatives such as the EuroHPC JU and the AI Factories, the European Open Science Cloud, and the AI, Data and Robotics Partnership under Horizon Europe.
Activities under the CSA topic should aim to establish robust coordination activities that foster interdisciplinary research collaboration between domain scientists and AI specialists and allow spreading excellence in AI and AI in science. A key focus should be on strengthening and connecting Horizon Europe-funded networks of excellence in AI in science and AI, through matchmaking events, regular communication activities, and a yearly RAISE summit. Applications should also support data collection curation and exchange, to enable pooling and sharing of scientific data within and across networks of excellence. In collaboration with the networks, it should organise workshops to identify grand scientific challenges that could be tackled with AI and contribute to the formulation of relevant domain-specific research agendas.
Read it on the EU portal ↗Answered 19 Aug 2025
Confirm the current call documents and submission conditions with the funding authority.
View on EU portal ↗Source: EU Funding & Tenders Portal · synced 2026-11-09
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